临床研究

早泄患者盐酸舍曲林治疗前后血清瘦素水平的变化

中华全科医师杂志 2012,11(12): 921-923.

对59例门诊早泄(PE)患者,予盐酸舍曲林治疗8周,观察治疗前后血浆瘦素水平的变化,同时评估射精潜伏期(IELT)、中国早泄患者性功能评价表(CIPE)评分的变化,并行相关性分析.59例PE患者治疗前血浆瘦素水平明显高于64例正常对照者,而IELT及CIPE评分远低于正常对照者;盐酸舍曲林治疗8周后,PE患者IELT及CIPE评分明显上升,血浆瘦素水平下降.表明血浆高水平瘦素是PE患者的生物学指标,其测定对临床诊断PE和评估疗效具有参考意义。

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贡献者信息

汤坤龙

300052 天津医科大学总医院泌尿外科

王宝龙

300052 天津医科大学总医院泌尿外科

杨琳

300052 天津医科大学总医院妇产科生殖医学中心

李黎明

300052 天津医科大学总医院泌尿外科

周勇

300052 天津医科大学总医院泌尿外科

杨长海

300052 天津医科大学总医院泌尿外科

关键词

早泄;瘦素

基金项目

天津医科大学科学基金资助(2011KY02)

历史

出版日期:2012-12-04

Changes of serum leptin levels in patients with premature ejaculation after sertraline treatment
TANG Kun-long,  WANG Bao-long,  LI Li-ming,  ZHOU Yong,  YANG Chang-hai
Published 2012-12-11
Cite as Chin J Gen Pract, 2012,11(12): 921-923. DOI: 10.3760/cma.j.issn.1671-7368.2012.12.013
Abstract

Fifty nine patients with premature ejaculation (PE) received sertraline treatment for 8 weeks.The average intravaginal ejaculation latency time (IELT) and the scores of Chinese index of premature ejaculation (CIPE) were evaluated and the fasting serum leptin levels were measured before and after treatment,all the values were compared with those of 64 normal male controls.The serum leptin levels were higher,the IELT and CIPE scores were lower in PE patients than those in normal controls before treatment.After 8 weeks of treatment with sertraline,the levels of serum leptin in PE patients decreased to normal levels,CIPE and IELT increased.The results indicate that serum leptin can be used as a bioindicator for diagnosis of premature ejaculation and assessment of therapeutic efficacy in PE patients.

Key words:

Premature ejaculation; Leptin

Contributor Information
TANG Kun-long
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China
WANG Bao-long
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China
LI Li-ming
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China
ZHOU Yong
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China
YANG Chang-hai
Department of Urology, Tianjin Medical University General Hospital, Tianjin 300052, China